- Computer-Aided Drug Design (CADD)
- DNA-Encoded Library Technology (DELT)
- Fragment-Based Screening
- High Content Screening (HCS)
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High Throughput Screening (HTS)
- Automated HTS Platform
- Biochemical assays in Hit Characterization
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Biophysical Assays in Hit Characterization
- BLI for Affinity-based Hit Screening
- CD Spectrometry for Protein Structure Determination
- ITC for Binding Assessment
- MS for Structure Confirmation
- MT for Binding Affinity Measurement
- NMR Spectrometry for Tareget identification and Characterization
- SPR Spectrometrys for Structure Determination
- TSA for Protein's Stability Evaluation
- Cellular assays in Hit Characterization
- Drug Repurposing
- Hit Screening
- HTS Assay Development
- HTS Compounds Libraries
- HTS Data Management
- Virtual Screening (VS)
One-stop
Drug Discovery Services
- Experienced and qualified scientists functioning as project managers or study director
- Independent quality unit assuring regulatory compliance
- Methods validated per ICH GLP/GMP guidelines
- Rigorous sample tracking and handling procedures to prevent mistakes
- Controlled laboratory environment to prevent a whole new level of success
DELT Data Analysis
INQUIRYSequencing data analysis refers to convert the screening results into the compounds encoded by these DNA tags in the form of DNA sequences. Molecular skeletons, reaction building blocks and library chemical reactions are general methods used in the DELT data analysis.
Fig.1 Schematic of DELT data analysis. (Potowski, M.; et al. 2019)Our Analysis Process and Services of DELT
We have designed an accurate algorithm to identify the enriched features from high-throughput sequencing data for the identification of target compounds. Our general analysis workflow is as follows:
Compare different samples for analysis according to the different mechanism of action of the compound.
Generate a file of the compound and DNA sequence quantity, attributes and other useful information.
Our Capabilities of DELT Data Analysis
We also propose a normalized z-score enrichment metric which applies a binomial distribution model that is relevant for analysis of DEL selection data.
BOC Sciences is equipped with automated system that allows for the automatic initiate of analysis once DNA sequencing is completed.
We traverse hundreds of 3D Data files with abundant signals.
Our Capabilities of DELT Data Analysis
Our experts have established a DELT data analysis automation platform to realize automatic data processing and reporting, which insignificantly increase the speed of data analysis and make timely data-driven decisions.
We are capable of reporting and delivering the screening results in about one day.
Our chemists also provide the downstream service: We can further confirm and select compounds for re-synthesis according to your project.
Reference
Potowski, M.; et al. Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions. Chemical Science. 2019, 45.
※ It should be noted that our service is only used for research.
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