Computer-Aided Drug Design
- ADME/Tox Prediction
- De Novo Drug Design
- Ligand-Based Virtual Screening
- Quantum Mechanics
- Structure-Based Virtual Screening
- DNA-Encoded Library Technology
- Fragment-Based Screening
- High Content Screening
High Throughput Screening
- Assay Development
- Automated HTS Platform
- Biochemical Assays
- Bio-Layer Interferometry
- Circular Dichroism Spectroscopy
- Isothermal Titration Calorimetry
- Mass Spectrometry
- Microscale Thermophoresis
- Nuclear Magnetic Resonance Spectrometry
- Surface Plasmon Resonance Spectrometry
- Thermal Shift Assay
- Cellular Assays
- Compound Libraries
- Data Management
- Drug Repurposing
- Hit Screening
- Virtual Screening
- Experienced and qualified scientists functioning as project managers or study director
- Independent quality unit assuring regulatory compliance
- Methods validated per ICH GLP/GMP guidelines
- Rigorous sample tracking and handling procedures to prevent mistakes
- Controlled laboratory environment to prevent a whole new level of success
The hit-to-lead optimization is a critical step to advance the molecules that have desired effects on its target into lead compounds with the required potency and pharmacokinetic properties for translation. Scientists take full advantages of massive DEL screening information for further detecting target pockets and providing composite optimization directions.
Our Optimization Procedure And Services
At BOC Sciences, our compound optimization is driven by the structure-signal relationship (SSR) analysis. SSR is performed on the basis of the same compound family, which means that the same chemical components involved in the compound are highly similar and they are related to the same biological activity.
Our analysis workflow is shown below:
Similarity search for confirmed hits.
Substitution diversity analysis and detailed substitution analysis.
Amendable to smaller alkyl substitution.
Strict requirement of linkage.
Some tolerance in heterocycle replacement.
We can utilize the obtained information from the structure-signal relationship to optimize the direction and actual selection of the structure.
Xuan, W.; et al. Diversified strategy for the synthesis of DNA-encoded oxindole libraries. Chemical Science. 2021, 12: 2841-2847.
※ It should be noted that our service is only used for research.